Cell Environment

2025

DNA Damage, Telomere and Centromere Dysfunction in Chromothripsis Rearrangements
Chromoanagenesis August 2025
Radhia M'kacher, Bruno Colicchio, Steffen Junker, Simon Schabat, Raja Belaiba, Louis Sontos, Leonhard Heidingsfelder, Wala Najar, Andreas Plesch, Philippe Voisin, Alain Dieterlen, Eric Jeandidier, Patrice Carde
DREPADetect: An Optimized YOLOv8 Model for High-Precision Detection of Sickle Cell
IEEE, Conference paper July 2025
Abdourahmane Balde, Simon Schabat, Avewe Bassene, Youssou Faye, Dieu-Donné Okalas Ossami, Ousmane Sall, Mamadou Soumboundou, Bruno Colicchio, Radhia M'kacher
2024

Chromosome localisation and segmentation in fluorescence microscopy images
Conference EUSIPCO August 2024
Simon Schabat, Bruno Colicchio, Jean-Baptiste Courbot, Alain Dieterlen, Radhia M'kacher
Telomere Dysfunction in Pediatric Patients with Differences/Disorders of Sexual Development
Biomedicines March 2024
Haifaou Younoussa, Macoura Gadji, Mamadou Soumboundou, Bruno Colicchio, Ahmed Said, Ndeye Aby Ndoye, Steffen Junker, Andreas Plesch, Leonhard Heidingsfelder, Ndeye Rama Diagne, Alain Dieterlen, Philippe Voisin, Patrice Carde, Eric Jeandidier, Radhia M'Kacher
Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma
Cell Reports 2023 Sep 26
David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc'his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M'kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall.
2023

Comparative Transcriptome Analyses in Mantle Cell Lymphoma (MCL): evidence of E2F1 As a Major Target in Aggressive Blastoid MCL Model
Blood November 28, 2023
Jusuf Imeri, Paul Marcoux, Christophe Desterke, Amen Allah Nasr, Radhia M'Kacher, Annelise Bennaceur Griscelli, Ali Turhan
Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma
Cell Reports 2023 Sep 26
David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc'his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M'kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall.
Extended lifespan and improved genome stability in HepaRG-derived cell lines through reprogramming by high-density stress
Proceedings of the National Academy of Sciences August 28, 2023
Charlotte Brun, Coralie Allain, Pierre-Jean Ferron, Haifaou Younoussa, Bruno Colicchio, Eric Jeandidier, Radhia M'Kacher, Christiane Guguen-Guillouzo, Fabrice Bertile.
Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs)
Cancers 2023 May 15
Gladys Telliam, Christophe Desterke, Jusuf Imeri, Radhia M’kacher, Noufissa Oudrhiri, Estelle Balducci, Micheline Fontaine-Arnoux, Hervé Acloque, Annelise Bennaceur-Griscelli, Ali G. Turhan.
High Resolution and Automatable Cytogenetic Biodosimetry Using In Situ Telomere and Centromere Hybridization for the Accurate Detection of DNA Damage: An Overview
International Journal of Molecular Sciences 2023 Mar 16
Radhia M'Kacher, Bruno Colicchio, Steffen Junker, Elie El Maalouf, Leonhard Heidingsfelder, Andreas Plesch, Alain Dieterlen, Eric Jeandidier, Patrice Carde, Philippe Voisin.
Deciphering the genetic and molecular mechanisms of disorders of sex development in Senegalese children in Sub-Saharan Africa
Genetics in Medicine Open January 2023
Haifaou Younoussa, Macoura Gadji, Mamadou Soumboundou, Rama Diagne, Radhia M'Kacher.
2022

Are Reed-Sternberg cells stuck in mitosis by short nucleoplasmic bridges as a consequence of centromeric instability?
HemaSphere 2022 Oct 6
Radhia M’Kacher, Steffen Junker, Bruno Colicchio, Wala Najar, Justyna Mika, Alain Dieterlen, Joanna Polanska, Philippe Voisin, Eric Jeandidier, Patrice Carde.
A Central Role of Telomere Dysfunction in the Formation of a Unique Translocation within the Sub-Telomere Region Resulting in Duplication and Partial Trisomy.
Genes 2022 Sep 29
M'Kacher R, Miguet M, Maillard PY, Colicchio B, Scheidecker S, Najar W, Arnoux M, Oudrhiri N, Borie C, Biehler M, Plesch A, Heidingsfelder L, Bennaceur- Griscelli A, Dieterlen A, Voisin P, Junker S, Carde P, Jeandidier E.
Patient-Derived iPSCs Reveal Evidence of Telomere Instability and DNA Repair Deficiency in Coats Plus Syndrome
Genes 2022 Aug 5
Oudrhiri N, M'kacher R, Chaker D, Colicchio B, Borie C, Jeandidier E, Dieterlen A, Griscelli F, Bennaceur-Griscelli A, Turhan AG
Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma.
Genetics in Medicine Open July 12, 2022
David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourchis, Elodie Girard, Jennifer Wong, Julien Masliah Planchon, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Mylene Bohec, Sylvain Baulande, Radhia M'kacher, Eric Jeandidier, André Nicolas, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J. Waterfall
Lung Fibroblasts from Idiopathic Pulmonary Fibrosis Patients Harbor Short and Unstable Telomeres Leading to Chromosomal Instability.
Biomedicines 2022 Feb 10
M'Kacher R, Jaillet M, Colicchio B, Vasarmidi E, Mailleux A, Dieterlen A, Kannengiesser C, Borie C, Oudrhiri N, Junker S, Voisin P, Jeandidier E, Carde P, Fenech M, Bennaceur-Griscelli A, Crestani B, Borie R.
2021

Is Response to Genotoxic Stress Similar in Populations of African and European Ancestry? A Study of Dose-Response After in vitro Irradiation.
Frontiers in Genetics 2021 Nov 11
Soumboundou M, Dossou J, Kalaga Y, Nkengurutse I, Faye I, Guingani A, Gadji M, Yameogo KJ, Zongo H, Mbaye G, Dem A, Diarra M, Adjibade R, Djebou C, Junker S, Oudrhiri N, Hempel WM, Dieterlen A, Jeandidier E, Carde P, El Maalouf E, Colicchio B, Bennaceur-Griscelli A, Fenech M, Voisin P, Rodriguez-Lafrasse C, M'Kacher R
Telomere aberrations, including telomere loss, doublets, and extreme shortening, are increased in patients with infertility.
Fertility and Sterility 2021 Jan 11
M'kacher R, Colicchio B, Marquet V, Borie C, Najar W, Hempel WM, Heidingsfelder L, Oudrhiri N, Al Jawhari M, Wilhelm-Murer N, Miguet M, Dieterlen A, Deschênes G, Tabet AC, Junker S, Grynberg M, Fenech M, Bennaceur-Griscelli A, Voisin P, Carde P, Jeandidier E, Yardin C.
2020

Telomere and centromere staining followed by M-FISH improves diagnosis of chromosomal instability and its clinical utility
Genes 27 April 2020
Radhia M’kacher, Bruno Colicchio, Claire Borie, Steffen Junker, Valentine Marquet, Leonhard Heidingsfelder, Kevin Soehnlen, Wala Najar, William M. Hempel, Noufissa Oudrhiri, Nadège Wilhelm, Marguerite Miguet, Micheline Arnoux, Catherine Ferrapie, Wendy Kerbrat, Andreas Plesch, Alain Dieterlen, Theodore Girinsky, Philippe Voisin, Georges Deschenes, Anne-Claude Tabet, Catherine Yardin, Annelise Bennaceur-Griscelli, Michael Fenech, Patrice Carde, and Eric Jeandidier.
A new tool for genotoxic risk assessment: Reevaluation of the cytokinesis-block micronucleus assay using semi-automated scoring following telomere and centromere staining
Mutation Research Genetic Toxicology and Environmental Genesis 2020 Febr-March
Zaguia, Eric Laplagne, Bruno Colicchio, Olivier Cariou , Mustafa Al Jawhari, Leonhard Heidingsfelder, William M. Hempel, Besma Bel Hadj Jrad, Eric Jeandidier, Alain Dieterlen, Patrice Carde, Philippe Voisin, Radhia M'kacher.
The Use of Natural Agents to Counteract Telomere Shortening: Effects of a Multi-Component Extract of Astragalus mongholicus Bunge and Danazol.
Biomedicines 2020 Feb 12
Guinobert I, Blondeau C, Colicchio B, Oudrhiri N, Dieterlen A, Jeandidier E, Deschenes G, Bardot V, Cotte C, Ripoche I, Carde P, Berthomier L, M'Kacher R.
2019

Biological Dosimetry Network in Africa: Establishment of a Dose-Response Curve Using Telomere and Centromere Staining.
Health Physics 2019 December
Soumboundou M, Nkengurutse I, Dossou J, Colicchio B, Djebou C, Gadji M, Houenon G, Dem A, Dedjan A, Diarra M, Adjibade R, Finot F, Hempel W, Dieterlen A, Jeandidier E, Rodriguez-Lafrasse C, M'kacher R.
Benefit of an association of an antioxidative substrate and a traditional Chinese medicine on telomere elongation. Cellular and Molecular Biology 2019 Dec 31
M’kacher, L.L. Breton, .B. Colicchio, H. Puget, W. Hempel, M. AL Jawhari, E. Jeandidier, and M. Frey.
Letter to the editor of environmental and molecular mutagenesis: In regard to Ramos et al.
Environmental and Molecular Mutagenesis 09 March 2019
2019 May. M'kacher R, Junker S, Jeandidier E, Carde P.
2018

Establishment and Characterization of a Reliable Xenograft Model of Hodgkin Lymphoma Suitable for the Study of Tumor Origin and the Design of New Therapies.
Cancers 2018 Oct 31
M'kacher R, Frenzel M, Al Jawhari M, Junker S, Cuceu C, Morat L, Bauchet AL, Stimmer L, Lenain A, Dechamps N, Hempel WM, Pottier G, Heidingsfelder L, Laplagne E, Borie C, Oudrhiri N, Jouni D, Bennaceur-Griscelli A, Colicchio B, Dieterlen A, Girinsky T, Boisgard R, Bourhis J, Bosq J, Mehrling T, Jeandidier E, Carde P.
Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability
Cancers 2018 Jul 13
Cuceu C, Colicchio B, Jeandidier E, Junker S, Plassa F, Shim G, Mika J, Frenzel M, Al Jawhari M, Hempel WM, O'Brien G, Lenain A, Morat L, Girinsky T, Dieterlen A, Polanska J, Badie C, Carde P, M'Kacher R.
The Transition between Telomerase and ALT Mechanisms in Hodgkin Lymphoma and Its Predictive Value in Clinical Outcomes.
Cancers 2018 May 30
M'kacher R, Cuceu C, Al Jawhari M, Morat L, Frenzel M, Shim G, Lenain A, Hempel WM, Junker S, Girinsky T, Colicchio B, Dieterlen A, Heidingsfelder L, Borie C, Oudrhiri N, Bennaceur-Griscelli A, Moralès O, Renaud S, Van de Wyngaert Z, Jeandidier E, Delhem N, Carde P.
Chromosomal Instability in Hodgkin Lymphoma: An In-Depth Review and Perspectives.
Cancers 2018 Mar 26
Cuceu C, Hempel WM, Sabatier L, Bosq J, Carde P, M'kacher R.
2017

Triradial and quadriradial chromosomes detected in a case of B-cell prolymphocytic leukaemia.
British Journal of Haematology 18 August 2017
Ittel A, Gervais C, Galoisy AC, M'Kacher R, Mauvieux L, Fornecker LM.
Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation
Scientific Reports 2017 Jun 12.
Kaddour A, Colicchio B, Buron D, El Maalouf E, Laplagne E, Borie C, Ricoul M, Lenain A, Hempel WM, Morat L, Al Jawhari M, Cuceu C, Heidingsfelder L, JeandidierE, Deschênes G, Dieterlen A, El May M, Girinsky T, Bennaceur-Griscelli A, Carde P, Sabatier L, M'kacher R.
Genotoxic risk of ethyl-paraben could be related to telomere shortening
Journal of Applied Toxicology Jan 12, 2017
Finot F, Kaddour A, Morat L, Mouche I, Zaguia N, Cuceu C, Souverville D, Négrault S, Cariou O, Essahli A, Prigent N, Saul J, Paillard F, Heidingsfelder L, Lafouge P, Al Jawhari M, Hempel WM, El May M, Colicchio B, Dieterlen A, Jeandidier E, Sabatier L, Clements J, M'Kacher R.

Publications